ACNE VULGARIS – ADEQUATE AND TIMELY THERAPY AS AN EARLY PREVENTION OF PSYCHOSOCIAL DISTURBANCES

Acne is a polyetiological chronic disease of pilosebaceous units that affects 80% to 90% of teenagers and adolescents. It is manifested as mild, moderate, or severe form. Since adolescence is time of psychological, emotional and social personality development, the appearance of acne, most frequently on face, demands long-term treatment, significantly affects psychologic and emotional state, creating the feeling of being marked and leading to depression, anxiety, social isolation and negative effect on the quality of life. Timely education, with general information on the causes, duration of the disease and adequate treatment can significantly affect patients’ relation to the disease and reduction of psycho-social problems. The analysis included 220, 39 (55%) males and 60 (45%) females, 14 to 30 years of age (or more), most frequently 16 to 20 years old with moderate form of the disease. Therapy was applied according to valid protocols. Each patient was given full attention with the explanation of the nature and course of the disease. The largest number of patients had the expected results, which was mutually appreciated. It was concluded that individual approach and cooperation during the treatment of each patient were necessary

Acute abdomen in a patient with Mayer-Rokitansky-Kuster-Hauser syndrome

Background. Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome is a malformation of female genital tract (incidence 1 in 4000 female newborn children). It appears as a result of a disorder in the development of Millerian cannals. Etiology is unknown. Syndrome MRKH is the most frequent cause of primary amenorrhoea (90%). Patients with MRKH have a normal female phenotype, with normal pubic hairness and thelarche, and female karyotype (46XX) followed by primary amenorrhoea. Hormonal status corresponds to healthy women, where the appearance of ovarian tumors and tumors on rudiment parts of uterus is possible. Case report. We presented a case of acute abdomen in a patient with previously not diagnosed MRKH. The diagnosis was done during the operation. Small pelvis and an abdominal part were filled with torquated tumor lump, where ovaries, oviducts, uterus or something resembling rudiment of uterus were not recognized through careful examination. Furthemore, the patient had a short, dead-end vagina. Tumorectomy was done and hystopathological finding showed the presence of vascular leiomyoma. Conclusion. The diagnosis of complex syndromes, such as MRKH, can, despite modern diagnostics, be absent for non-medical and psycho-social reasons. We can expect ovarian and uterine pathology on hypoplastic structures in these patients, as well as in healthy women. Vascular leiomyoma in the patients with MRKH was not found in the available literature

Simultano inženjerstvo utemeljeno na virtualnoj proizvodnji

U radu je razmatran koncept konkurentnog inženjeringa koji podrazumijeva simultane aktivnosti u integriranom razvoju proizvoda i procesa, kroz primjenu inovativnih tehnologija virtualnog inženjeringa, posebno u dijelu simulacije proizvodnje, tzv. virtualne proizvodnje. Cilj je da se minimiziraju projektne izmjene u kasnijim fazama projektiranja, a time i vrijeme i troškovi projektiranja proizvoda i pripadajućih procesa. Primjena FE/FV simulacija može eliminirati skupe fizičke prototipove i eksperimente. Vrijeme razvoja se drastično smanjuje, više projektnih alternativa se može provjeriti, što rezultira povećanjem kvalitete. Primjena koncepta ilustrirana je brojnim primjerima numeričkih simulacija proizvodnih procesa korišćenjem SIMUFACT.forming softvera: oblikovanje debljih limova, kovanje, "net-shape" obrada, toplo istiskivanje profila, itd

Concurrent engineering based on virtual manufacturing

U radu je razmatran koncept konkurentnog inženjeringa koji podrazumijeva simultane aktivnosti u integriranom razvoju proizvoda i procesa, kroz primjenu inovativnih tehnologija virtualnog inženjeringa, posebno u dijelu simulacije proizvodnje, tzv. virtualne proizvodnje. Cilj je da se minimiziraju projektne izmjene u kasnijim fazama projektiranja, a time i vrijeme i troškovi projektiranja proizvoda i pripadajućih procesa. Primjena FE/FV simulacija može eliminirati skupe fizičke prototipove i eksperimente. Vrijeme razvoja se drastično smanjuje, više projektnih alternativa se može provjeriti, što rezultira povećanjem kvalitete. Primjena koncepta ilustrirana je brojnim primjerima numeričkih simulacija proizvodnih procesa korišćenjem SIMUFACT.forming softvera: oblikovanje debljih limova, kovanje, "net-shape" obrada, toplo istiskivanje profila, itd.The paper deals with the concurrent engineering concept that implies simultaneous activities in integrated product and process development, through the application of Virtual Engineering Technologies, especially in the simulation of production, i.e. Virtual Manufacturing. The main goal is to minimize design modifications in final design stages, and therewith time and costs of design of product and related processes. Expensive physical prototypes and experiments can be avoided by applying numerical FE/FV simulations. Development time is drastically decreased; many design alternatives can be verified, leading to quality improvements. Application of CE concept is illustrated through numerous case studies of numerical simulations of processes using SIMUFACT.forming software: thick sheet forming, forging, net-shape forming, hot profile extrusion, etc

Application of quantum chemical calculation in defining peaks in uv-vis spectra of oxidative tartrazine degradation

Degradation of tartrazine in presence of cobalt activated Oxone® (potassium peroxymonosulfate) was investigated. Aluminium pillared clay acted as a support for catalytically active Co2+. Oxone® was a precursor of SO4˙ˉ radical anions. Along with decolorization of tartrazine solution, the degradation of tartrazine and formation of oxidation products was monitored using UV-Vis spectroscopy. Quantum chemical calculations were performed in order to predict UV-Vis spectra. Different models were tested, and the results of calculation have shown that the combination of TPSS-D3 method and aug-cc-pVDZ basis set is quite satisfactory level of theory. The experimentally obtained peaks that arose during degradation were identified using this method

26th Annual Computational Neuroscience Meeting (CNS*2017): Part 3 - Meeting Abstracts - Antwerp, Belgium. 15–20 July 2017

This work was produced as part of the activities of FAPESP Research,\ud Disseminations and Innovation Center for Neuromathematics (grant\ud 2013/07699-0, S. Paulo Research Foundation). NLK is supported by a\ud FAPESP postdoctoral fellowship (grant 2016/03855-5). ACR is partially\ud supported by a CNPq fellowship (grant 306251/2014-0)

Geometries of stacking interactions between phenanthroline ligands in crystal structures of square-planar metal complexes

Stacking interactions of phenanthroline square-planar complexes in crystal structures were studied by analyzing data from the Cambridge Structural Database. In most of the crystal structures, two phenanthroline complexes were oriented "head to tail." Phenanthroline complexes show a wide range of overlap geometries in stacking interactions, while short metal-metal distances were not observed. Stacking chains with alternating overlaps were the predominant type of packing in the crystal structures

FREQUENCY OF CERVICAL INTRAEPITHELIAL NEOPLASIA AND CARCINOMAS IN WOMEN WITH AND WITHOUT BACTERIAL VAGINOSIS

Bacterial vaginosis is one of the most frequent disorders of vaginal ecosystem in women during their reproductive life. The first concept in the pathogenesis of bacterial vaginosis points out that the unfamiliar initial influence on vaginal ecosystem decreases lactobacillus concentration, which results in the increase of vaginal secretion pH and multiplication of Gardnerela vaginalis and other anaerobes. The aim of this study was to compare the frequency of cervical neoplasia in women with and without bacterial vaginosis. The research included 158 patients, between 18 and 51 years of age, at the Clinic of Gynecology and Obstetrics in Niš. Clinical processing of patients consisted of cytological, colposcopic and pathohistological examinations. Bacterial vaginosis was, beside clue cell detection with native preparation, diagnosed by the application of other Amsel’s criteria: presence of characteristic vaginal secretion, positive amino test, values of vaginal secretion pH over 4.5. The results showed that 23.42% of the patients had bacterial vaginosis. The greatest percent of the patients with bacterial vaginosis (24.32%) was between 20 and 34 years of age. In the examined population, 7.59% of the patients had positive pathohistological finding. The number of normal pathohistological findings was statistically significantly lower in the patients with bacterial vaginosis (75.68%) than in those without bacterial vaginosis (97.52%), (χ2=16.28, p<0.001)

Molar-incisor hypomineralization: Therapeutic challenge to paediatric dentistry practice

Introduction: Molar incisor hypomineralization indicates the appearance of enamel hypomineralization of systemic origin which occurs in 1-4 first permanent molars, which is often accompanied by changes on permanent incisors. Variations in clinical manifestation, together with commonly present asymmetry, are the reason for large variations in the needs for therapeutic treatment of these structural enamel defects. Case study: Two patients with diagnosed molar incisor hypomineralization are shown. The first patient, a six-year-old girl, with diagnosed mild clinical form, visited the dentist immediately after the eruption of the first permanent molars. Early diagnosis and timely application of preventive-profilactic measures, together with mild clinical form, are the reason for prevention of dental caries and further spreading of posteruptive enamel breakdown on affected first molars. Unlike the first one, the second patient, a 7,5-year-old girl had the diagnosis of moderate molar incisor hypomineralization. She developed dental caries on tooth 46 as well as complication in dental caries on tooth 36 which was extracted soon after the eruption. Conclusion: Early diagnosis and the severity of clinical appearance are the most important factors which determine therapeutic outcome of the treatment of molar incisor hypomineralization